This paper deals with intercultural differences in business communication between Europe and Asia. The paper investigates the differences in business communication between four European countries: Germany, Great Britain, Italy and Spain and four Asian countries: Japan, China, India and Saudi Arabia. It was established that there are several general similarities in business communication between Asia and Europe, and that the differences are much more pronounced. The similarities are of a general nature and include the general importance of business communication, the aspiration to develop long-term relationships, the manner and style of dressing, the necessity of knowing the rules of business communication and avoiding conflicts. The differences are more numerous and more pronounced, and include different styles of communication, different importance of hierarchy in the company, different importance of non-verbal communication, different perception of time, different tendency to express feelings, different way of greeting, different importance of gifts and presents, etc. Cross-cultural differences between different countries, especially those that are geographically more distant, are necessary to know for the success of business communication and achieving business cooperation with members of other cultures. If the person who performs business communication is not competent enough to communicate with members of other cultures, not only the company's reputation is at risk, but also business cooperation with partners, and ultimately the result of the business. For this reason, the conclusion arises that the company should have professional staff who will be in charge of business communication and who will continuously develop and improve their knowledge, abilities, skills and competences.